Honey bee microRNAs respond to infection by the microsporidian parasite Nosema ceranae

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Abstract
In order to study the effects ofNosema ceranaeinfection on honey bee microRNA (miRNA) expression, we deep-sequenced honey bee miRNAs daily across a full 6-day parasite reproduction cycle. Seventeen miRNAs were differentially expressed in honey bees infected byN. ceranaethat potentially target over 400 genes predicted to primarily involve ion binding, signaling, the nucleus, transmembrane transport and DNA binding. Based on Enzyme Code analysis, nine biological pathways were identified by screening target genes against the Kyoto Encyclopedia of Genes and Genomes (KEGG) database, seven of which involved metabolism. Our results suggest that differentially expressed miRNAs regulate metabolism related genes of host honey bees in response toN. ceranaeinfection.

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