The role of K63-linked polyubiquitin in several types of autophagy
Authors:
Open Access
- 2 May 2022
- journal article
- review article
- Published by Springer Nature in Biologia Futura
- Vol. 73 (2) , 137-148
Abstract
Lysosomal-dependent self-degradative (autophagic) mechanisms are essential for the maintenance of normal homeostasis in all eukaryotic cells. Several types of such self-degradative and recycling pathways have been identified, based on how the cellular self material can incorporate into the lysosomal lumen. Ubiquitination, a well-known and frequently occurred posttranslational modification has essential role in all cell biological processes, thus in autophagy too. The second most common type of polyubiquitin chain is the K63-linked polyubiquitin, which strongly connects to some self-degradative mechanisms in the cells. In this review, we discuss the role of this type of polyubiquitin pattern in numerous autophagic processes.Keywords
Funding Information
- Nemzeti Kutatási, Fejlesztési és Innovaciós Alap (PD135447)
- New National Excellence Program of the Ministry for Innovation and Technology from the Source of the National Research, Development and Innovation Fund (ÚNKP-21-4-II-ELTE-60)
- Magyar Tudományos Akadémia (Bolyai)
- Eötvös Loránd University
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