TBAF-Catalyzed Synthesis of 5-Substituted 1H-Tetrazoles under Solventless Conditions
- 20 March 2004
- journal article
- research article
- Published by American Chemical Society (ACS) in The Journal of Organic Chemistry
- Vol. 69 (8) , 2896-2898
Abstract
Tetrabutylammonium fluoride (TBAF) is an efficient catalyst in the [3 + 2] cycloaddition reaction of organic nitriles 1 with trimethylsilyl azide (TMSN3) in solventless conditions. The corresponding 5-substituted 1H-tetrazoles 2 were obtained under mild conditions and in 80−97% yields.Keywords
This publication has 2 references indexed in Scilit:
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- Three synthetic routes to a sterically hindered tetrazole. A new one-step mild conversion of an amide into a tetrazoleThe Journal of Organic Chemistry, 1991