A placebo-controlled blind trial of cyclosporin-A in prevention of corneal graft rejection in rabbits.

Authors:
  • TBT A Bell
    T A Bell
  • DED L Easty
    D L Easty
  • KMK G McCullagh
    K G McCullagh
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Abstract
Cyclosporin-A (CyA) administered to rabbits intramuscularly in a dose of 25 mg/kg/day for 14 days following interlamellar corneal grafting had a significant effect in preventing rejection of the corneal graft (p less than 0.05), and the benefit was maintained. Rejection was attended by an initial mild inflammatory reaction and followed by a protracted intense response involving a variety of cell types, with subsequent loss of epithelium. endothelium and keratocytes, and the development of areas of stromal necrosis. CyA suppressed this rejection response.