Supplementary Methods, Figure Legends, Tables S1 - S4 from An Acquired HER2 T798I Gatekeeper Mutation Induces Resistance to Neratinib in a Patient with HER2 Mutant–Driven Breast Cancer

Authors:
  • AHAriella B. Hanker
    Ariella B. Hanker
  • MBMonica Red Brewer
    Monica Red Brewer
  • JSJonathan H. Sheehan
    Jonathan H. Sheehan
  • JKJames P. Koch
    James P. Koch
  • GSGregory R. Sliwoski
    Gregory R. Sliwoski
  • RNRebecca Nagy
    Rebecca Nagy
  • RLRichard Lanman
    Richard Lanman
  • MBMichael F. Berger
    Michael F. Berger
  • DHDavid M. Hyman
    David M. Hyman
  • DSDavid B. Solit
    David B. Solit
  • JHJie He
    Jie He
  • VMVincent Miller
    Vincent Miller
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Abstract
Supplementary Table S1. Summary of mutations identified by FoundationOne profiling of the original, pre-neratinib skin metastasis. Supplementary Table S2. Frequency of HER2L869R and HER2T798I mutations. Supplementary Table S3. Sequencing of plasma DNA. Supplementary Table S4. ERBB2 targeted capture.