Gene of the month: NKX3.1
Authors:
- 7 January 2022
- journal article
- research article
- Published by BMJ in Journal of Clinical Pathology
- Vol. 75 (6) , 361-364
Abstract
NKX3.1 is a multifaceted protein with roles in prostate development and protection from oxidative stress. Acting as a pioneer factor, NKX3.1 interacts with chromatin at enhancers to help integrate androgen regulated signalling. In prostate cancer, NKX3.1 activity is frequently reduced through a combination of mutational and post-translational events. Owing to its specificity for prostate tissue, NKX3.1 has found use as an immunohistochemical marker in routine histopathology practice.Keywords
Funding Information
- Pathological Society of Great Britain and Ireland (JSPS-CPHD-2018-01)
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