Cerebral arterial spasm

Authors:
  • GAGeorge S. Allen
    George S. Allen
  • CGCarol J. Gross
    Carol J. Gross
  • LFLyle A. French
    Lyle A. French
  • SCShelley N. Chou
    Shelley N. Chou
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Abstract
✓ In vitro experiments were performed with a small volume chamber to determine the contractile activity of various vasoactive agents on human basilar and anterior cerebral arteries. Cumulative log-dose response curves were obtained for most of the agents tested including serotonin and three different prostaglandins; many of these curves were found to be similar to curves previously obtained with canine cerebral arteries. It was concluded from these similarities that canine cerebral arteries are a good in vitro model for studying human cerebral arterial spasm. It was also demonstrated that human cerebrospinal fluid, collected up to 17 days after a subarachnoid hemorrhage from patients with clinical and angiographic evidence of cerebral arterial spasm, would cause large, dose-dependent contractions in human anterior cerebral arteries.

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