Parallel synthesis of 3-aryloxy-2-propanolamines and evaluation as dual affinity 5-HT1A and 5-HT re-uptake ligands
Authors:
- Monique B. van NielMNMonique B. van Niel
- Margaret S. BeerMBMargaret S. Beer
- Josél. CastroJCJosél. Castro
- Susan K.F. ChengSCSusan K.F. Cheng
- David C. EvansDEDavid C. Evans
- Anne HealdAHAnne Heald
- Laure HitzelLHLaure Hitzel
- Peter HuntPHPeter Hunt
- Russell Mortishire-SmithRMRussell Mortishire-Smith
- Desmond O'COnnorDODesmond O'COnnor
- Alan P. WattAWAlan P. Watt
- Angus M. MacLeodAMAngus M. MacLeod
- 1 November 1999
- journal article
- Published by Elsevier in Bioorganic & Medicinal Chemistry Letters
- Vol. 9 (22) , 3243-3248
Abstract
No abstract availableKeywords
This publication has 21 references indexed in Scilit:
- Solid phase synthesis of unsymmetrical secondary amines—Application to the synthesis of arylethanolamines and arylpropanolaminesTetrahedron Letters, 1998
- A Soluble Polymer Approach to the “Fishing Out” Principle: Synthesis and Purification of β-Amino AlcoholsThe Journal of Organic Chemistry, 1998
- Effect of a selective 5‐HT reuptake inhibitor in combination with 5‐HT1A and 5‐HT1B receptor antagonists on extracellular 5‐HT in rat frontal cortex in vivoBritish Journal of Pharmacology, 1997
- Solution-phase synthesis of a β-amino alcohol combinatorial libraryBioorganic & Medicinal Chemistry Letters, 1997
- Randomised, double-blind, placebo-controlled trial of pindolol in combination with fluoxetine antidepressant treatmentThe Lancet, 1997
- Drug Treatment of Depression in the 1990sDrugs, 1996
- Antagonism of Serotonin 5‐HT1A Receptors Potentiates the Increases in Extracellular Monoamines Induced by Duloxetine in Rat HypothalamusJournal of Neurochemistry, 1996
- Acceleration of the effect of selected antidepressant drugs in major depression by 5-HT1A antagonistsTrends in Neurosciences, 1996
- Effectiveness of Pindolol With Selected Antidepressant Drugs in the Treatment of Major DepressionJournal of Clinical Psychopharmacology, 1995
- Pindolol Induces a Rapid Improvement of Depressed Patients Treated With Serotonin Reuptake InhibitorsArchives of General Psychiatry, 1994