Stratodynamics: A Layered Theory of Biological Response from Bernard’s Milieu Intérieur to Modern Systems Physiology

Author:
Preprint
Publisher website
Google Scholar
Abstract
Physiology has long explained organismal stability through homeostasis, allostasis, feedback regulation, and related systems concepts. These frameworks remain essential, but each is most precise at a particular scale or mode of response. This manuscript proposes stratodynamics as a layered theory of biological response in vertebrate physiology. The framework holds that biological response is organized through seven functional layers: molecular, subcellular, cellular, tissue, organ, systemic, and organismal. Each layer reduces its own form of mismatch between actual and required state through a scale-appropriate architecture: molecular-state transition, intracellular integration, cellular-state transition, tissue program, organ output, systemic feedback, or organismal anticipation. The layers are coupled upward, downward, and laterally, allowing local events to become systemic responses and allowing organismal state to shape lower-layer readiness. Stratodynamics therefore locates rather than replaces previous theories: homeostasis is preserved as the canonical systemic architecture, allostasis as organismal predictive regulation, and tissue repair, resolution biology, bioelectricity, and thermodynamic self-organization as complementary layer-specific contributors. The framework is presented as a theoretical synthesis and research program for veterinary and medical sciences.

This publication has 60 references indexed in Scilit: