Double Banking on Knowledge: A Unified All-in-One Framework for Unpaired Multi-Modality Semi-Supervised Medical Image Segmentation

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Abstract
Multi-modality (MM) semi-supervised learning (SSL) based medical image segmentation has recently gained increasing attention for its ability to utilize MM data and reduce reliance on labeled images. However, current methods face several challenges: (1) Multiple networks assignment hinder scalability to scenarios with more than two modalities. (2) Focusing solely on modality-invariant representation while neglecting modality-specific features, leads to incomplete MM learning. (3) Leveraging unlabeled data with generative methods can be unreliable for SSL. To address these problems, we propose a novel unified all-in-one framework for MM-SSLmedical image segmentation. To address challenge (1), we propose a modality all-in-one segmentation network based on standard U-Net architecture that accepts data from all modalities, removing the limitation on modality count. To address challenge (2), we design two learnable plug-in banks, Modality-Level Modulation bank (MLMB) and Modality-Level Prototype (MLPB) bank, to capture both modality-invariant and modality-specific knowledge. These banks are updated using our proposed Modality Prototype Contrastive Learning (MPCL). Additionally, we design Modality Adaptive Weighting (MAW) to dynamically adjust learning weights for each modality, ensuring balanced MM learning as different modalities learn at different rates. Finally, to address challenge (3), we introduce a Dual Consistency (DC) strategy that enforces consistency at both the image and feature levels without relying on generative methods. We evaluate our method on a 2-to-4 modality segmentation task using three open-source datasets, and extensive experiments show that our method outperforms state-of-the-art approaches. The source code is publicly available at https://github.com/CYYukio/Double-Knowledge-Banking.
Funding Information
  • National Natural Science Foundation of China (62271335)
  • Sichuan Science and Technology Program (2025ZNSFSC0470)

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