Surfactant Protein A Enhances the Degradation of LPS-Induced TLR4 in Primary Alveolar Macrophages Involving Rab7, β-arrestin2, and mTORC1
- 17 February 2022
- journal article
- research article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 90 (2) , e0025021
Abstract
Respiratory infections by Gram-negative bacteria are a major cause of global morbidity and mortality. Alveolar macrophages (AMs) play a central role in maintaining lung immune homeostasis and host defense by sensing pathogens via pattern recognition receptors (PRR).Keywords
Funding Information
- Bundesministerium für Forschung, Technologie und Raumfahrt
- Deutsche Forschungsgemeinschaft
- Deutsche Forschungsgemeinschaft
- Deutsches Zentrum für Lungenforschung
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