Surfactant Protein A Enhances the Degradation of LPS-Induced TLR4 in Primary Alveolar Macrophages Involving Rab7, β-arrestin2, and mTORC1

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Abstract
Respiratory infections by Gram-negative bacteria are a major cause of global morbidity and mortality. Alveolar macrophages (AMs) play a central role in maintaining lung immune homeostasis and host defense by sensing pathogens via pattern recognition receptors (PRR).
Funding Information
  • Bundesministerium für Forschung, Technologie und Raumfahrt
  • Deutsche Forschungsgemeinschaft
  • Deutsche Forschungsgemeinschaft
  • Deutsches Zentrum für Lungenforschung

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