The Meaning of Interaction
- 8 December 2010
- journal article
- research article
- Published by S. Karger AG in Human Heredity
- Vol. 70 (4) , 269-277
Abstract
Although recent studies have attempted to dispel the confusion that exists in regard to the definition, analysis and interpretation of interaction in genetics, there still remain aspects that are poorly understood by non-statisticians. After a brief discussion of the definition of gene-gene interaction, the main part of this study addresses the fundamental meaning of statistical interaction and its relationship to measurement scale, disproportionate sample sizes in the cells of a two-way table and gametic phase disequilibrium.Keywords
This publication has 23 references indexed in Scilit:
- Using biological networks to search for interacting loci in genome-wide association studiesEuropean Journal of Human Genetics, 2009
- Epistasis — the essential role of gene interactions in the structure and evolution of genetic systemsNature Reviews Genetics, 2008
- Improving Power in Contrasting Linkage-Disequilibrium Patterns between Cases and ControlsThe American Journal of Human Genetics, 2007
- Dynamic genome architecture in the nuclear space: regulation of gene expression in three dimensionsNature Reviews Genetics, 2007
- Powerful Multilocus Tests of Genetic Association in the Presence of Gene-Gene and Gene-Environment InteractionsThe American Journal of Human Genetics, 2006
- Test for Interaction between Two Unlinked LociThe American Journal of Human Genetics, 2006
- A gene-centric approach to genome-wide association studiesNature Reviews Genetics, 2006
- Epistasis: what it means, what it doesn't mean, and statistical methods to detect it in humansHuman Molecular Genetics, 2002
- Molecular Structure of Nucleic Acids: A Structure for Deoxyribose Nucleic AcidNature, 1953
- THE INTERACTION OF NATURE AND NURTUREAnnals of Eugenics, 1946