The delta subunit of the GABAA receptor is necessary for the GPT2-promoted breast cancer metastasis
Open Access
- 1 January 2023
- journal article
- research article
- Published by Ivyspring International Publisher in Theranostics
- Vol. 13 (4) , 1355-1369
Abstract
Objectives: Glutamic pyruvate transaminase (GPT2) catalyzes the reversible transamination between alanine and α-ketoglutarate (α-KG) to generate pyruvate and glutamate during cellular glutamine catabolism. The glutamate could be further converted to γ-aminobutyric acid (GABA). However, the role of GPT2 in tumor metastasis remains unclear.Keywords
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