Genetic variation in hepcidin expression and its implications for phenotypic differences in iron metabolism
Authors:
- H. K. BayeleHBH. K. Bayele
- S. K. S. SraiSSS. K. S. Srai
- 1 September 2009
- journal article
- Published by Ferrata Storti Foundation (Haematologica) in Haematologica
- Vol. 94 (9) , 1185-1188
Abstract
Iron homeostasis, like other physiological processes, relies on precise and timely interactions between key proteins involved in either its uptake or release. At the core of this is hepcidin, a small acute phase antimicrobial peptide that now also appears to synchronously orchestrate the response ofKeywords
This publication has 24 references indexed in Scilit:
- Association of hepcidin promoter c.-582 A>G variant and iron overload in thalassemia majorHaematologica, 2009
- Epigenetic regulation and the variability of gene expressionNature Genetics, 2008
- Cis and trans regulation of hepcidin expression by upstream stimulatory factorBlood, 2006
- Interleukin-6 induces hepcidin expression through STAT3Blood, 2006
- Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expressionNature Genetics, 2006
- Structural variation in the human genomeNature Reviews Genetics, 2006
- A Portuguese patient homozygous for the -25G>A mutation of the HAMP promoter shows evidence of steady-state transcription but fails to up-regulate hepcidin levels by ironBlood, 2005
- The genomics of gene expressionGenomics, 2004
- Strain and gender modulate hepatic hepcidin 1 and 2 mRNA expression in miceBlood Cells, Molecules, and Diseases, 2004
- Molecular Analysis of Mammalian Circadian RhythmsAnnual Review of Physiology, 2001