Stereoselective Synthesis of MLN4924, an Inhibitor of NEDD8-Activating Enzyme
Authors:
- 21 March 2011
- journal article
- research article
- Published by American Chemical Society (ACS) in The Journal of Organic Chemistry
- Vol. 76 (9) , 3557-3561
Abstract
MLN4924 (1), which is in clinical trials as an anticancer agent, was stereoselectively synthesized from d-ribose via a route involving stereoselective reduction, regioselective cleavage of an isopropylidene moiety, and selective displacement of a cyclic sulfate moiety as key steps.Keywords
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