Non-volatile fatty acids in the diagnosis of non-specific vaginitis.

Authors:
  • CIC A Ison
    C A Ison
  • CEC S Easmon
    C S Easmon
  • SDS G Dawson
    S G Dawson
  • GSG Southerton
    G Southerton
  • JHJ W Harris
    J W Harris
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Abstract
In the vaginal washings of 100 women with symptomatic non-specific vaginitis a succinate/lactate ratio of greater than or equal to 0.4 had a diagnostic sensitivity of 80%, a specificity of 83% for this condition. The predictive value of a positive test was 94%, but that of a negative test was only 55%. A strong association between the presence of Gardnerella vaginalis, anaerobes, a vaginal pH of above 4.5, and amines was found not only in non-specific vaginitis, but also in trichomonal and gonococcal infection. A variety of primary changes may encourage the multiplication of both gardnerellae and anaerobes and their presence in non-specific vaginitis may be a secondary rather than a primary event.

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