Autotransfusion of 3H-Cytidine-Labelled Blood Lymphocytes in Patients with Hodgkin’s Disease and Non-Hodgkin Patients

Authors:
  • PSP. Schick
    P. Schick
  • FTF. Trepel
    F. Trepel
  • MEM. Eder
    M. Eder
  • MMM. Matzner
    M. Matzner
  • SBS. Benedek
    S. Benedek
  • HTH. Theml
    H. Theml
  • WKW. Kaboth
    W. Kaboth
  • HBH. Begemann
    H. Begemann
  • TFT.M. Fliedner
    T.M. Fliedner
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Abstract
The dilution in the circulating blood of lymphocytes labelled in vitro with 3H-cytidine was examined after autotransfusion in 9 patients with Hodgkin’s disease (HD) stage II A-IV B, 5 of whom were untreated; in 2 untreated patients with carcinoma, and in 1 treated patient with scleroderma. The blood transit time of exchangeable lymphocytes was 37+18 min in the patients with HD and 26+6 min in the other patients. The proportion of exchangeable (recirculating) small blood lymphocytes was 39–84% in HD and 81-91% in the carcinoma patients. The relation between the size of the circulating pool of small blood lymphocytes and the total exchangeable (recirculating) lymphocyte pool was 1:20 to 1:30 in HD and 1:29 to 1:34 in the other patients. The absolute size of the recirculating pool of lymphocytes was 46-90 × 109 cells in HD and 100-150 x109 cells in the carcinoma patients.