Analysis of Neuron-Specific Enolase and S100B as Biomarkers of Cognitive Decline Following Surgery in Older People
Authors:
- Emma L. JonesEJEmma L. Jones
- Nathan GaugeNGNathan Gauge
- Odd Bjarte NilsenONOdd Bjarte Nilsen
- David LoweryDLDavid Lowery
- Keith WesnesKWKeith Wesnes
- Eirini KatsaitiEKEirini Katsaiti
- James ArdenJAJames Arden
- Derek AmoakoDADerek Amoako
- Nicholas ProphetNPNicholas Prophet
- Balaji PurushothamanBPBalaji Purushothaman
- David GreenDGDavid Green
- Clive BallardCBClive Ballard
- 30 November 2012
- journal article
- Published by S. Karger AG in Dementia and Geriatric Cognitive Disorders
- Vol. 34 (5-6) , 307-311
Abstract
Post-operative cognitive decline is frequent in older individuals following major surgery; however, biomarkers of this decline are less clearly defined. Sixty-eight participants over the age of 60 provided blood samples at baseline and 24 h post-surgery. Cognitive decline was measured at baseline and 52 weeks post-surgery using the Cambridge Assessment for Mental Disorder in the Elderly, section B (CAMCOG) score. Plasma levels of neuron-specific enolase (NSE) and S100B were measured by ELISA. Baseline NSE and the change in NSE levels between baseline and 24 h were correlated with the change in CAMCOG score between baseline and 52 weeks. NSE concentrations may be a useful predictor of individuals at risk of more severe long-term cognitive decline.Keywords
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