A CINful way to overcome addiction: how chromosomal instability enables cancer to overcome its oncogene addiction

Authors:
Open Access
Publisher website
Google Scholar
Abstract
Oncogene‐addicted tumors present a valuable target for therapeutic intervention and an opportunity to achieve a wide therapeutic window. Nonetheless, resistance to targeted therapies is frequently observed and it arises through multiple mechanisms, including mutations in the target gene. Chromosomal instability, a defining feature of human cancer, has been linked to targeted therapy resistance, but the mechanism underlying this association is poorly understood. In the current issue of EMBO Molecular Medicine , Salgueiro et al show that chromosomal instability can lead to the generation of alternative oncogenic drivers, thereby providing the ability for cancer cells to overcome the oncogene withdrawal bottleneck. Importantly, this study shows that, by generating de novo genomic diversity, chromosomal instability serves as an adaptive response to therapeutic insult.
Funding Information
  • NIH Office of the Director (DP5OD026395)
  • Burroughs Wellcome Fund
  • Josie Robertson Foundation
  • Parker Institute for Cancer Immunotherapy

This publication has 10 references indexed in Scilit: