Lipids and All-Cause Mortality among Older Adults: A 12-Year Follow-Up Study
Open Access
- 1 January 2012
- journal article
- Published by Hindawi Limited in The Scientific World Journal
- Vol. 2012, 1-5
Abstract
This is a 12-year follow-up cohort study with 800 people (60–85 years old). The association between lipid disorders and mortality was analysed by Cox proportional hazard adjusted model. All-cause mortality was considered the dependent variable, and lipid disorders as independent variables: total cholesterol (TC) >200 and 50. An initial analysis of all subjects was performed and a second was carried out after having excluded individuals with a body mass index (BMI) 2or mortality in ≤2 years. The mortality showed a positive association with low TC and a negative association with high TC and high LDL-c. After the exclusion of underweight and premature mortality, there was a positive association only with TC <170 mg/dl (HR = 1.36, CI95%: 1.02–1.82). The data did not show a higher risk with high levels of TC, LDL-c, and TG. However, they showed higher mortality among older adults with low TC.Keywords
This publication has 23 references indexed in Scilit:
- Importance of high-density lipoprotein-cholesterol (HDL-C) levels to the incidence of cardiovascular disease (CVD) in the elderlyArchives of Gerontology and Geriatrics, 2011
- Serum total cholesterol levels and all-cause mortality in a home-dwelling elderly population: a six-year follow-upScandinavian Journal of Primary Health Care, 2010
- Relation of plasma lipids to all-cause mortality in Caucasian, African-American and Hispanic eldersAge and Ageing, 2008
- Low total cholesterol predicts mortality in the nondemented oldest oldArchives of Gerontology and Geriatrics, 2007
- Serum High-Density Lipoprotein Cholesterol Levels and Mortality in Frail, Community-Living ElderlyGerontology, 2007
- Low‐Density Lipoprotein Cholesterol and Mortality in Older PeopleJournal of the American Geriatrics Society, 2005
- Relationship Between Plasma Lipids and All‐Cause Mortality in Nondemented ElderlyJournal of the American Geriatrics Society, 2005
- Low Total Cholesterol and Increased Risk of Dying: Are Low Levels Clinical Warning Signs in the Elderly? Results from the Italian Longitudinal Study on AgingJournal of the American Geriatrics Society, 2003
- Lack of association between cholesterol and coronary heart disease mortality and morbidity and all-cause mortality in persons older than 70 years1994
- Total serum cholesterol levels and mortality risk as a function of age. A report based on the Framingham dataArchives of internal medicine (1960), 1993