Controlled hydrophobic/hydrophilicity of chitosan for spheres without specific processing technique
- 1 January 2003
- journal article
- research article
- Published by Wiley in Biopolymers
- Vol. 69 (3) , 386-390
Abstract
Chitosan is functionalized with phthalic anhydride at the amino group and poly(ethylene glycol) methyl ether at the hydroxyl group via homogeneous reaction. The product regenerated forms particles in either aqueous solution or organic solvents. The particles are spheres with the size of few micrometers as observed from scanning electronmicroscopy. The present work demonstrates that by simply adjusting the hydrophilicity and hydrophobicity, we can directly obtain spheres without a specific processing technique. © 2003 Wiley Periodicals, Inc. Biopolymers 69: 386–390, 2003Keywords
This publication has 20 references indexed in Scilit:
- Hydrophobic Chain Conjugation at Hydroxyl Group onto γ-Ray Irradiated ChitosanBiomacromolecules, 2001
- Transmission Electron Microscopic Study of Cross-Sectional Morphologies of Core−Corona Polymeric NanospheresMacromolecules, 2000
- Polyacrylamide-Chitosan Hydrogels: In Vitro Biocompatibility and Sustained Antibiotic Release StudiesDrug Delivery, 2000
- Chitosan microspheres: modification of polymeric chem-physical properties of spray-dried microspheres to control the release of antibiotic drugJournal of Applied Polymer Science, 1999
- A multiple emulsion method to entrap a lipophilic compound into chitosan microspheresInternational Journal of Pharmaceutics, 1997
- Controlled release of piroxicam from chitosan beadsInternational Journal of Pharmaceutics, 1995
- Collagen-chitosan composite membranes for controlled release of propranolol hydrochlorideInternational Journal of Pharmaceutics, 1995
- Synthesis and antitumor activity of 6-O-carboxymethyl chitin fixing 5-fluorouracils through pentamethylene, monomethylene spacer groups via amide, ester bonds.Chemical and Pharmaceutical Bulletin, 1992
- Modelling of drug release from pellets coated with an insoluble polymeric membraneJournal of Controlled Release, 1991
- Chemospecific manipulations of a rigid polysaccharide: syntheses of novel chitosan derivatives with excellent solubility in common organic solvents by regioselective chemical modificationsMacromolecules, 1991