The tyrosine phosphatase SHP-1 promotes T cell adhesion by activating the adaptor protein CrkII in the immunological synapse
- 8 August 2017
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science Signaling
- Vol. 10 (491)
Abstract
Targeting the phosphorylation state of a T cell adaptor protein may enable modulation of T cell adhesion and activation.Keywords
Funding Information
- National Institutes of Health (award292382)
- National Institute of Allergy and Infectious Diseases (award292383)
- Rheumatology Research Foundation (award292384)
- Irma T. Hirschl Trust (award292385)
This publication has 73 references indexed in Scilit:
- Rap1-interacting adapter molecule (RIAM) associates with the plasma membrane via a proximity detectorJournal of Cell Biology, 2012
- SKAP1 Protein PH Domain Determines RapL Membrane Localization and Rap1 Protein Complex Formation for T Cell Receptor (TCR) Activation of LFA-1Journal of Biological Chemistry, 2011
- Structural basis for regulation of the Crk signaling protein by a proline switchNature Chemical Biology, 2010
- Control of cell adhesion dynamics by Rap1 signalingCurrent Opinion in Cell Biology, 2009
- Phospholipase D1 Regulates Lymphocyte Adhesion via Upregulation of Rap1 at the Plasma MembraneMolecular and Cellular Biology, 2009
- T Cell ActivationAnnual Review of Immunology, 2009
- The WAVE2 complex regulates T cell receptor signaling to integrins via Abl- and CrkL–C3G-mediated activation of Rap1Journal of Cell Biology, 2008
- Proline cis-trans Isomerization Controls Autoinhibition of a Signaling ProteinMolecular Cell, 2007
- T Cell Receptor-Proximal Signals Are Sustained in Peripheral Microclusters and Terminated in the Central Supramolecular Activation ClusterImmunity, 2006
- Actin and agonist MHC–peptide complex–dependent T cell receptor microclusters as scaffolds for signalingJournal of Experimental Medicine, 2005