In vivo and in vitro Effect of Bradykinin on Bronchial Motor Tone in Normal Subjects and Patients with Airways Obstruction

Authors:
  • BSB.G. Simonsson
    B.G. Simonsson
  • BSB.-E. Skoogh
    B.-E. Skoogh
  • NBN.P. Bergh
    N.P. Bergh
  • RAR. Andersson
    R. Andersson
  • NSN. Svedmyr
    N. Svedmyr
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Abstract
The bronchoconstrictory effect of bradykinin was studied in vivo on subjects with normal airways and on patients with airways ob struction and in vitro on isolated muscle preparations. Body plethysmographic measurements ofe airways conductance showed that bradykinin in both groups caused bronchoconstriction which probably was due to non-specific irritation of vagal irritant receptors, as it could be blocked by atropine in all but 3 obstructive patients. In these, we assume a more specific direct muscle-constricting effect from bradykinin. The in vitro tests revealed a widerange of sensitivity to bradykinin; muscles from patients with airways obstructionshowed an increased sensitivity to bradykinin.