Lymphocyte calcium signaling from membrane to nucleus
- 15 December 2005
- journal article
- review article
- Published by Springer Nature in Nature Immunology
- Vol. 7 (1) , 25-32
Abstract
Ca2+ signals control a variety of lymphocyte responses, ranging from short-term cytoskeletal modifications to long-term changes in gene expression. The identification of molecules and channels that modulate Ca2+ entry into T and B lymphocytes has both provided details of the molecular events leading to immune responses and raised controversy. Here we review studies of the pathways that allow Ca2+ entry, the function of Ca2+ in the regulation of cell polarity and motility and the principles by which Ca2+-dependent transcription regulates lymphocyte function.Keywords
This publication has 164 references indexed in Scilit:
- STIM1 is a Ca2+ sensor that activates CRAC channels and migrates from the Ca2+ store to the plasma membraneNature, 2005
- STIM Is a Ca2+ Sensor Essential for Ca2+-Store-Depletion-Triggered Ca2+ InfluxCurrent Biology, 2005
- Phospholipase Cγ1 controls surface expression of TRPC3 through an intermolecular PH domainNature, 2005
- Targeted disruption of mouse ortholog of the human MYH9 responsible for macrothrombocytopenia with different organ involvement: hematological, nephrological, and otological studies of heterozygous KO miceBiochemical and Biophysical Research Communications, 2004
- A single class II myosin modulates T cell motility and stopping, but not synapse formationNature Immunology, 2004
- Phospholipase C-γ Is Required for Agonist-Induced Ca2+ EntryCell, 2002
- NFAT SignalingCell, 2002
- Effect of Cytochalasins on F-Actin and Morphology of Ehrlich Ascites Tumor CellsExperimental Cell Research, 2000
- Vav is a regulator of cytoskeletal reorganization mediated by the T-cell receptorCurrent Biology, 1998
- Imaging antigen recognition by naive CD4+ T cells: compulsory cytoskeletal alterations for the triggering of an intracellular calcium responseEuropean Journal of Immunology, 1998