Phase II study of carboplatin as a single drug for relapsed Wilms' tumor: Experience of the Brazilian Wilms' tumor study group
Authors:
- Renato MelaragnoRMRenato Melaragno
- Nagsla Saba E SilvaNSNagsla Saba E Silva
- Nubia MendonclaNMNubia Mendoncla
- Maria Nunes AlvaresMAMaria Nunes Alvares
- Elizabeth MorinakaEMElizabeth Morinaka
- Armando MarquesAMArmando Marques
- Maria P. CusatoMCMaria P. Cusato
- 1 January 1994
- journal article
- clinical trial
- Published by Wiley in Medical and Pediatric Oncology
- Vol. 22 (4) , 258-260
Abstract
A total of 15 patients with relapsed Wilms' tumor were treated with carboplatin as a single agent. There were six females and nine males, aged between 2 and 9 years (me‐dian:5). The treatment consisted of carboplatin given I.V. as a single agent at a dose of 550 mg/m2 over 1 hour every 3 weeks. There were four (26%) complete responses, four (26%) partial responses, one stable disease, and six with progressive disease. In all patients a total of 56 courses were given and the toxicities found were leukopenia and thrombocytopenia. The overall response rate was encouraging and the toxicity was acceptable and reversible.Keywords
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