Tumoreek, estres sozialak eta estresari aurre egiteko estrategiek jokabide depresiboan eta garunaren aktibitatean duten eragina
Open Access
- 15 June 2017
- journal article
- Published by Udako Euskal Unibertsitatea in Osagaiz: osasun-zientzien aldizkaria
- Vol. 1 (1)
Abstract
Depresioak lotura estua du minbiziarekin eta estres sozialarekin, baina harreman hori eragiten duten mekanismoen inguruko informazioa ez dago erabat osatuta. Hori dela-eta, tumoreek eta estresak garunaren aktibitatean duten eragina aztertzea izan du helburu ikerketa honek. Horretarako, Oncins France 1 (OF1) sagu arrei B16F10 melanoma zelulak inokulatu eta azpitalde bati estres soziala eragin zaio. Tumoreak garuneko serotonina-maila murriztu eta 3-HK neurotoxikoaren maila handitu du. Azken efektu hori estresari aurre egiteko estrategia pasiboak dituzten saguetan ere azaldu da. Jokaerari dagokionez, tumoreak sakarosarekiko preferentzia txikitu eta eremu irekiko proban gelditasuna handitu ditu. Ondorioz, tumoreak bide toxikoa aktibatu eta jokaera depresiboak areagotu dituela adierazten dute datuek.Keywords
This publication has 12 references indexed in Scilit:
- Anxiety and depression after cancer diagnosis: Prevalence rates by cancer type, gender, and ageJournal of Affective Disorders, 2012
- A meta-analysis of differences in IL-6 and IL-10 between people with and without depression: Exploring the causes of heterogeneityBrain, Behavior, and Immunity, 2012
- Psychoneuroimmunology Meets Neuropsychopharmacology: Translational Implications of the Impact of Inflammation on BehaviorNeuropsychopharmacology, 2011
- The new ‘5-HT’ hypothesis of depression: Cell-mediated immune activation induces indoleamine 2,3-dioxygenase, which leads to lower plasma tryptophan and an increased synthesis of detrimental tryptophan catabolites (TRYCATs), both of which contribute to the onset of depressionProgress in Neuro-Psychopharmacology and Biological Psychiatry, 2011
- Organization of the stress system and its dysregulation in melancholic and atypical depression: high vs low CRH/NE statesMolecular Psychiatry, 2002
- Serotonin 1A Receptors, Serotonin Transporter Binding and Serotonin Transporter mRNA Expression in the Brainstem of Depressed Suicide VictimsNeuropsychopharmacology, 2001
- Social status in mice: behavioral, endocrine and immune changes are context dependentPhysiology & Behavior, 2001
- A primer on cytokines: sources, receptors, effects, and inducersClinical Microbiology Reviews, 1997
- Evidence for an immune response in major depression: A review and hypothesisProgress in Neuro-Psychopharmacology and Biological Psychiatry, 1995
- THE CATECHOLAMINE HYPOTHESIS OF AFFECTIVE DISORDERS: A REVIEW OF SUPPORTING EVIDENCEAmerican Journal of Psychiatry, 1965