Penicillin concentrations in cerebrospinal fluid (CSF) during repository treatment regimen for syphilis.
Authors:
- E J KraaiEKE J Kraai
- P C van Voorst VaderPVP C van Voorst Vader
- H Haaxma-ReicheHHH Haaxma-Reiche
- J A SnijderJSJ A Snijder
Open Access
- 1 August 1988
- journal article
- Published by BMJ in Sexually Transmitted Infections
- Vol. 64 (4) , 223-225
Abstract
Penicillin concentrations in cerebrospinal fluid (CSF) were measured in 40 asymptomatic patients with syphilis, 10 of whom had neurosyphilis. The patients were treated with 2.4 MIU procaine penicillin a day intramuscularly in combination with 500 mg probenecid every six hours orally. This intramuscular treatment regimen did not consistently yield treponemicidal penicillin concentrations in the CSF (subtreponemicidal CSF concentrations were found in 17 patients, four of whom had neurosyphilis). These data provide additional evidence that the cure of asymptomatic neurosyphilis is not guaranteed by intramuscular penicillin treatment.Keywords
This publication has 10 references indexed in Scilit:
- Penicillin concentrations in serum and CSF during high‐dose intravenous treatment for neurosyphilisNeurology, 1987
- Syphilis in the AIDS EraNew England Journal of Medicine, 1987
- Effect of early and late syphilis on central nervous system: cerebrospinal fluid changes and neurological deficit.Sexually Transmitted Infections, 1987
- Neurosyphilis after treatment of latent syphilis with benzathine penicillin.Sexually Transmitted Infections, 1986
- Survival of treponemes after treatment: comments, clinical conclusions, and recommendations.Sexually Transmitted Infections, 1985
- Relationship between neurological features and intrathecal synthesis of IgG antibodies to Treponema pallidum in untreated and treated human neurosyphilisJournal of Neurology, 1983
- Central nervous system involvement in early syphilis. Part 1. Intrathecal immunoglobulin productionActa Dermato-Venereologica, 1983
- Penicillin concentrations in cerebrospinal fluid and serum after intramuscular, intravenous, and oral administration to syphilitic patientsActa Dermato-Venereologica, 1983
- Production of treponemicidal concentration of penicillin in cerebrospinal fluid.BMJ, 1981
- Diagnosis of neurosyphilis by examination of the cerebrospinal fluid.Sexually Transmitted Infections, 1981