A USEFUL METHOD FOR THE SYNTHESIS OF MACROCYCLIC LACTONE
Authors:
- 5 August 1978
- journal article
- research article
- Published by Oxford University Press (OUP) in Chemistry Letters
- Vol. 7 (8) , 885-888
Abstract
Long chain hydroxy acids were converted into macrocyclic lactones in high yields by the treatment with 2-chloro-6-methyl-1,3-diphenylpyridinium tetrafluoroborate, 2,6-dimethylpyridine (or 2,4,6-triphenylpyridine) and benzyltriethylammonium chloride. The lactonization reaction was successfully applied to the synthesis of (R) - (+)-ricinelaidic acid lactone, and prostaglandin F2α 1,9- and 1,15-lactones.Keywords
This publication has 2 references indexed in Scilit:
- Synthese des (R)‐trans‐11‐Hydroxy‐8‐dodecensäure‐lactons (Recieifeiolid)Helvetica Chimica Acta, 1976
- Synthesis of novel macrocyclic lactones in the prostaglandin and polyether antibiotic seriesJournal of the American Chemical Society, 1975