Seven-membered ring nucleobases as inhibitors of human cytidine deaminase and APOBEC3A
Open Access
- 7 June 2023
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Organic & Biomolecular Chemistry
- Vol. 21 (24) , 5117-5128
Abstract
A DNA hairpin possessing 1,3-diazepin-2-one 2′-deoxyriboside or 5-fluoro-2′-deoxyzebularine in its loop inhibits APOBEC3A in the nM range in vitro .Keywords
Funding Information
- Health Research Council of New Zealand (20/1355)
- Massey University (7003)
- Massey University (MURF 2015)
- Massey University (RM20734)
- Maurice Wilkins Centre for Molecular Biodiscovery
- Palmerston North Medical Research Foundation
- Worldwide Cancer Research (16-1197)
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