Genetic and Epigenetic Control of Heart Development
Authors:
- 9 December 2019
- journal article
- research article
- Published by Cold Spring Harbor Laboratory in Cold Spring Harbor Perspectives in Biology
- Vol. 12 (7) , a036756
Abstract
A transcriptional program implemented by transcription factors and epigenetic regulators governs cardiac development and disease. Mutations in these factors are important causes of congenital heart disease. Here, we review selected recent advances in our understanding of the transcriptional and epigenetic control of heart development, including determinants of cardiac transcription factor chromatin occupancy, the gene regulatory network that regulates atrial septation, the chromatin landscape and cardiac gene regulation, and the role of Brg/Brahma-associated factor (BAF), nucleosome remodeling and histone deacetylation (NuRD), and Polycomb epigenetic regulatory complexes in heart development.Keywords
This publication has 79 references indexed in Scilit:
- A reference map of murine cardiac transcription factor chromatin occupancy identifies dynamic and conserved enhancersNature Communications, 2019
- Divergent Requirements for EZH1 in Heart Development Versus RegenerationCirculation Research, 2017
- EED orchestration of heart maturation through interaction with HDACs is H3K27me3-independenteLife, 2017
- Disease Model of GATA4 Mutation Reveals Transcription Factor Cooperativity in Human CardiogenesisCell, 2016
- Endocardial Brg1 disruption illustrates the developmental origins of semilunar valve diseaseDevelopmental Biology, 2015
- YY1 DNA binding and interaction with YAF2 is essential for Polycomb recruitmentNucleic Acids Research, 2013
- ChIP-Seq identification of weakly conserved heart enhancersNature Genetics, 2010
- Gata4 is required for maintenance of postnatal cardiac function and protection from pressure overload-induced heart failureProceedings of the National Academy of Sciences, 2006
- Cardiac Septal and Valvular Dysmorphogenesis in Mice Heterozygous for Mutations in the Homeobox Gene Nkx2-5Circulation Research, 2000
- Mutations in human cause limb and cardiac malformation in Holt-Oram syndromeNature Genetics, 1997