Inhibition of peroxisome proliferator‐activated receptor gamma activity in esophageal carcinoma cells results in a drastic decrease of invasive properties

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Abstract
Esophageal cancer is difficult to treat because of its rapid progression, and more effective therapeutic approaches are needed. The PPARγ is a nuclear receptor superfamily member that is expressed in many cancers. PPARγ expression is a feature of esophageal cancer cell lines, and in the present investigation, the PPARγ antagonists T0070907 and GW9662 could induce loss of invasion but could not induce growth reduction or apoptosis at low concentrations (Cancer Sci 2006; 97: 854–860)

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