Histamine is an Intracellular Messenger Mediating Platelet Aggregation
Authors:
- Lorne J. BrandesLBLorne J. Brandes
- Allan B. BeckerABAllan B. Becker
- Keith J. SimonsKSKeith J. Simons
- Frank S. LaBellaFLFrank S. LaBella
- Jon M. GerrardJGJon M. Gerrard
- 24 March 1989
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 243 (4898) , 1596-1599
Abstract
Inhibition of human platelet aggregation byN,N-diethyl-2-[4-(phenylmethyl)phenoxy]ethanamine-HCl (DPPE), a novel antagonist of histamine binding, suggested that histamine might serve a critical role in cell function. Phorbol-12-myristate-13-acetate (PMA) or collagen was found to increase platelet histamine content in parallel with promotion of aggregation. Inhibitors of histidine decarboxylase (HDC) suppressed both aggregation and the elevation of histamine content, whereas DPPE inhibited aggregation only. In saponin-permeabilized platelets, added histamine reversed the inhibition by DPPE or HDC inhibitors on aggregation induced by PMA or collagen. The results indicate a role for histamine as an intracellular messenger, which in platelets promotes aggregation.Keywords
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