The Neural Crest and the Origin of the Insulin-Producing and Other Gastrointestinal Hormone-Producing Cells
Authors:
- 16 January 1976
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 191 (4223) , 191-192
Abstract
It has been proposed that the endocrine cells of the digestive tract derive from the neuroectoderm (neural crest). To test this hypothesis we removed the entire ectoderm, the precursor of the neural crest, of embryonic rats prior to the formation of the neural crest and cultured the mesoendoderm for 11 days. In every case where a pancreas developed, insulin was detected or B cells were observed. Thus, a neural crest origin for these cells is eliminated.Keywords
This publication has 13 references indexed in Scilit:
- Immunocytochemical confirmation of the neural crest origin of avian calcitonin-producing cellsHistochemistry and Cell Biology, 1974
- Development, differentiation and derivation of the endocrine polypeptide cells of the mouse pancreasDiabetologia, 1973
- A feulgen-positive nucleolusExperimental Cell Research, 1973
- Effects of a partially purified factor from chick embryos on macromolecular synthesis of embryonic pancreatic epitheliaDevelopmental Biology, 1973
- A biological cell labeling technique and its use in experimental embryologyDevelopmental Biology, 1973
- Neural crest origin of the endocrine polypeptide (APUD) cells of the gastrointestinal tract and pancreasGut, 1971
- Fluorogenic amine tracing of neural crest derivatives forming the adrenal medullaGeneral and Comparative Endocrinology, 1971
- THE CYTOCHEMISTRY AND ULTRASTRUCTURE OF POLYPEPTIDE HORMONE-PRODUCING CELLS OF THE APUD SERIES AND THE EMBRYOLOGIC, PHYSIOLOGIC AND PATHOLOGIC IMPLICATIONS OF THE CONCEPTJournal of Histochemistry & Cytochemistry, 1969
- THE ENDOCRINE CELLS IN THE EPITHELIUM OF THE GASTROINTESTINAL MUCOSA OF THE RATJournal of Cell Biology, 1969
- Early pancreas organogenesis: Morphogenesis, tissue interactions, and mass effectsDevelopmental Biology, 1967