Base-catalyzed bicyclization of dialkyl glutaconates with cinnamoylacetamides: a synthetic strategy for isoquinolinedione derivatives
- 17 April 2014
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Chemical Communications
- Vol. 50 (49) , 6458-6460
Abstract
We report here that polysubstituted dihydroisoquinolones and isoquinolones can be constructed by the one-pot reaction of the readily available acyclic α,β-unsaturated carbonyl precursors and dialkyl glutaconates under mild basic conditions (1–45 min for the former vs. 1–6 h for the latter) via the domino process involving [3+3] annulation/intramolecular aza-cyclization.Keywords
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