New Hemisynthetic Manoyl Oxide Derivatives with Antimicrobial Activity.
- 1 January 2001
- journal article
- Published by Pharmaceutical Society of Japan in Chemical and Pharmaceutical Bulletin
- Vol. 49 (7) , 814-817
Abstract
The synthesis and antimicrobial activity of ten labdane-type diterpenes derived from ent-3-beta-hydroxy-13-epi-manoyl oxide (ribenol) is reported. The chloroethyl carbamidic ester 9 showed the strongest antimicrobial activity against all the tested gram (+), gram (-) bacteria and pathogenic fungi. Moreover, the glycoside 11 exhibited an interesting activity against the three tested fungi.Keywords
This publication has 18 references indexed in Scilit:
- In Vitro Platelet-Activating Factor Receptor Binding Inhibitory Activity of Pinusolide Derivatives: A Structure−Activity StudyJournal of Medicinal Chemistry, 1998
- Antibacterial Labdane-type Diterpenes from the Resin “Ladano” ofCistus creticus Subsp. creticusNatural Product Letters, 1998
- In Vitro Action of ent-Manoyl Oxides against Leishmania donovaniJournal of Natural Products, 1997
- Cytotoxic and Antibacterial Labdane-Type Diterpenes from the Aerial Parts ofCistus incanussubsp.creticusPlanta Medica, 1994
- Cell Differentiation-Inducing Diterpenes from Andrographis paniculata NEES.Chemical and Pharmaceutical Bulletin, 1994
- Synthesis and Glycosidation Reactions of 3-Halo-2,3,6-trideoxy-L-arabino-hexopyranosesSynthesis, 1992
- A derivative of ent-13-epi-manoyl oxide isolated from Sideritis javalambrensisPhytochemistry, 1989
- 2,4-Diamino-5-benzylpyrimidines and analogs as antibacterial agents. 9. Lipophilic trimethoprim analogs as antigonococcal agentsJournal of Medicinal Chemistry, 1988
- Clinical Pharmacokinetics of IndomethacinClinical Pharmacokinetics, 1981
- Chemistry of the Podocarpaceae. LV. Conversion of 8α, 13-Epoxylabd-14-en-2-one into 3β-Hydroxy-13, 14, 15, 16-tetranorlabd-8(17)-en-12-oic acidAustralian Journal of Chemistry, 1980