Anti‐inflammatory activity of mushroom‐derived hispidin through blocking of NF‐κB activation

Authors:
Publisher website
Google Scholar
Abstract
BACKGROUND: Hispidin, a polyphenol compound mainly derived from the valuable medicinal mushroom Phellinus species, has been found to possess distinct biological effects. However, the anti‐inflammatory potential of hispidin still remains uncharacterized.RESULTS: In this study, the effects of hispidin on activation of nuclear factor kappa B (NF‐κB) and the subsequent production of inducible nitric oxide synthase (iNOS) were determined in the lipopolysaccharide (LPS)‐induced macrophage RAW 264.7 cells. Our data indicated that hispidin inhibits transcriptional activity of NF‐κB in a dose‐dependent manner. Hispidin also attenuated LPS‐induced NF‐κB nuclear translocation and associated inhibitor of kappa B (IκB‐α) degradation. Furthermore, hispidin deceased iNOS protein expression and the generation of reactive oxygen species (ROS) in the LPS‐induced cells, but did not affect phosphorylation of mitogen‐activated protein kinases.CONCLUSION: These findings suggest that hispidin exhibits anti‐inflammatory activity through suppressing ROS mediated NF‐κB pathway in mouse macrophage cells. © 2014 Society of Chemical Industry

This publication has 20 references indexed in Scilit: