Transfer of T6SSSPI-19 from Salmonella Gallinarum to Salmonella Typhimurium Lacking T6SSSPI-6 Complements its Colonization Defect in Mice
Open Access
- 1 June 2023
- journal article
- research article
- Published by Polish Society of Microbiologists in Polish Journal of Microbiology
- Vol. 72 (2) , 215-219
Abstract
Salmonella genus harbors five Type VI Secretion System (T6SS) gene clusters. The T6SS encoded in SPI-6 (T6SSSPI-6) contributes to Salmonella Typhimurium colonization of chickens and mice, while the T6SS encoded in SPI-19 (T6SSSPI-19) of Salmonella Gallinarum contributes to chicken colonization. Interestingly, the T6SSSPI-19 of Salmonella Gallinarum complemented the defect in chicken colonization of a Salmonella Typhimurium strain that lacks the T6SSSPI-6, suggesting that both T6SSs are interchangeable. Here we show that the transfer of Salmonella Gallinarum T6SSSPI-19 complemented the defect in mice colonization of a Salmonella Typhimurium ΔT6SSSPI-6 strain, indicating that both T6SSs are functionally redundant during host colonization.Keywords
This publication has 29 references indexed in Scilit:
- Structural Insights into the Effector – Immunity System Tae4/Tai4 from Salmonella typhimuriumPLOS ONE, 2013
- The Type VI Secretion System Encoded in SPI-6 Plays a Role in Gastrointestinal Colonization and Systemic Spread of Salmonella enterica serovar Typhimurium in the ChickenPLOS ONE, 2013
- The Type VI Secretion System Encoded in Salmonella Pathogenicity Island 19 Is Required for Salmonella enterica Serotype Gallinarum Survival within Infected MacrophagesInfection and Immunity, 2013
- Structure of the Type VI Effector-Immunity Complex (Tae4-Tai4) Provides Novel Insights into the Inhibition Mechanism of the Effector by Its Immunity Protein*Journal of Biological Chemistry, 2013
- Type VI Secretion System-Associated Gene Clusters Contribute to Pathogenesis of Salmonella enterica Serovar TyphimuriumInfection and Immunity, 2012
- Salmonella bongori Provides Insights into the Evolution of the SalmonellaePLOS Pathogens, 2011
- The Type VI Secretion System: A Multipurpose Delivery System with a Phage-Like MachineryMolecular Plant-Microbe Interactions®, 2011
- Comparative genomic analysis uncovers 3 novel loci encoding type six secretion systems differentially distributed in Salmonella serotypesBMC Genomics, 2009
- sciS , an icmF Homolog in Salmonella enterica Serovar Typhimurium, Limits Intracellular Replication and Decreases VirulenceInfection and Immunity, 2005
- VEX-capture: a new technique that allows in vivo excision, cloning, and broad-host-range transfer of large bacterial genomic DNA segmentsJournal of Microbiological Methods, 2004