Ischemic stroke risk, smoking, and the genetics of inflammation in a biracial population: the stroke prevention in young women study
Authors:
- John W ColeJCJohn W Cole
- David W BrownDBDavid W Brown
- Wayne H GilesWGWayne H Giles
- Oscar C StineOSOscar C Stine
- Jeffrey R O'ConnellJOJeffrey R O'Connell
- Braxton D MitchellBMBraxton D Mitchell
- John D SorkinJSJohn D Sorkin
- Marcella A WozniakMWMarcella A Wozniak
- Barney J SternBSBarney J Stern
- Mary J SparksMSMary J Sparks
- Mark T DobbinsMDMark T Dobbins
- Latasha T ShoffnerLSLatasha T Shoffner
Open Access
- 1 January 2008
- journal article
- research article
- Published by Springer Nature in Thrombosis Journal
- Vol. 6 (1) , 11
Abstract
Although cigarette smoking is a well-established risk factor for vascular disease, the genetic mechanisms that link cigarette smoking to an increased incidence of stroke are not well understood. Genetic variations within the genes of the inflammatory pathways are thought to partially mediate this risk. Here we evaluate the association of several inflammatory gene single nucleotide polymorphisms (SNPs) with ischemic stroke risk among young women, further stratified by current cigarette smoking status.Keywords
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