Specific binding sites for 5-hydroxytryptamine on rat blood platelets
Authors:
- A H DrummondADA H Drummond
- J L GordonJGJ L Gordon
- 1 July 1975
- journal article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 150 (1) , 129-132
Abstract
5-Hydroxytryptamine changes the shape of rat blood platelets by combination with a cinanserin-sensitive receptor which is not associated with the active uptake of 5-hydroxytryptamine. Binding of 5-hydroxy[3H]tryptamine to platelets at 4°C demonstrates the presence of three saturable sites, and the highest-affinity site is apparently this 5-hydroxytryptamine receptor.Keywords
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