Acute myocardial infarction (AMI) is a severe coronary condition with potentially fatal consequences. Currently, the standard of care is to perform thromboaspiration followed by stent implantation as part of percutaneous coronary intervention. However, due to the thrombus load and vasoconstriction of the artery during the procedure, there is a tendency to underestimate vessel size, resulting in selection of a stent that will be smaller than the artery after clot resolution and vasodilation. This potentially increases the risk of stent malapposition and subsequent stent thrombosis. A novel self-expandable stent was recently developed; preliminary results from the APPOSITION I study demonstrate its feasibility in the treatment of AMI and its ability to follow the enlargement of the artery with near perfect apposition. This self-expandable stent may therefore become an important tool in the treatment of AMI.