Diabetes alters drug metabolism-in vivo studies in a streptozotozin-diabetic rat model
Authors:
- 1 May 1986
- journal article
- research article
- Published by Springer Nature in Cellular and Molecular Life Sciences
- Vol. 42 (5) , 560-562
Abstract
The influence of experimental streptozotozin-induced diabetes on hepatic drug metabolism in vivo has been studied in rats, using14CO2-exhalation after14C-aminopyrine injection. Male diabetic rats showed a decreased (−18%), females an increased (+19%)14CO2-exhalation compared to controls, indicating altered hepatic drug metabolism due to diabetes.Keywords
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