Reductive radical decarboxylation of amino-acids and peptides

Authors:
  • DBDerek H. R. Barton
    Derek H. R. Barton
  • YHYolande Hervé
    Yolande Hervé
  • PPPierre Potier
    Pierre Potier
  • JTJosiane Thierry
    Josiane Thierry
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Abstract
Radicals generated from N-protected α-amino-acids by photolysis of their N-hydroxypyridine-2-thione esters at room temperature are efficiently quenched by t-butyl thiol to give decarboxy-acids; comparable reactions have been carried out on the side chain carboxy groups of suitably protected aspartic and glutamic acids.
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