Diffusely Abnormal White Matter in Chronic Multiple Sclerosis
Authors:
- Alexandra SeewannASAlexandra Seewann
- Hugo VrenkenHVHugo Vrenken
- Paul van der ValkPVPaul van der Valk
- Erwin L. A. BlezerEBErwin L. A. Blezer
- Dirk L. KnolDKDirk L. Knol
- Jonas A. CastelijnsJCJonas A. Castelijns
- C. H. PolmanCPC. H. Polman
- Petra J. W. PouwelsPPPetra J. W. Pouwels
- Frederik BarkhofFBFrederik Barkhof
- Jeroen J. G. GeurtsJGJeroen J. G. Geurts
Open Access
- 1 May 2009
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of Neurology
- Vol. 66 (5) , 601-609
Abstract
Multiple sclerosis (MS) is a chronic, inflammatory, demyelinating disease of the central nervous system typically characterized by focal lesions in the white matter (WM). Magnetic resonance imaging (MRI) is the most sensitive imaging technique for detecting MS lesions in vivo, and lesion load measurements based on conventional T2-weighted MRI are widely used to monitor treatment effects in therapeutic trials.1 However, there is only a modest correlation between the lesion load on conventional MRI and the clinical disability of patients with MS, a phenomenon referred to as clinicoradiologic dissociation.2Keywords
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