Effect of Medication on Synovial Fluid Leukocyte Differentials in Patients With Rheumatoid Arthritis
Authors:
- H. Ralph SchumacherHSH. Ralph Schumacher
Open Access
- 7 October 1991
- journal article
- research article
- Published by Wiley in Arthritis & Rheumatism
- Vol. 34 (9) , 1173-1176
Abstract
We compared leukocyte populations in synovial fluid samples from 45 rheumatoid arthritis patients, grouped according to medications taken. Seventeen of the 22 patients receiving only nonsteroidal antiinflammatory drugs had lymphocytes as the single predominant cell. None of the 23 patients receiving second-line agents had lymphocyte predominance. These findings may have important implications for drug mechanisms and must be considered in future studies of synovial fluid.Keywords
This publication has 10 references indexed in Scilit:
- Enhanced prostaglandin E2 secretion by cytokine‐stimulated human synoviocytes in the presence of subtherapeutic concentrations of nonsteroidal antiinflammatory drugsArthritis & Rheumatism, 1990
- The cyclo‐oxygenase inhibitor, Piroxicam, enhances cytokine‐induced lymphocyte proliferation in vitro and in vivoImmunology & Cell Biology, 1990
- Inhibition of in vitro vascular endothelial cell proliferation and in vivo neovascularization by low‐dose methotrexateArthritis & Rheumatism, 1989
- Effect of indomethacin on swelling, lymphocyte influx, and cartilage proteoglycan depletion in experimental arthritis.Annals of the Rheumatic Diseases, 1989
- The american rheumatism association 1987 revised criteria for the classification of rheumatoid arthritisArthritis & Rheumatism, 1988
- Assessment of Immune Response During Chrysotherapy: Comparison of Gold Sodium Thiomalate vs. AuranofinScandinavian Journal of Rheumatology, 1981
- High-affinity binding sites for prostaglandin E on human lymphocytesCellular Immunology, 1979
- Action of chloroquine phosphate in rheumatoid arthritis. 1. Immunosuppressive effect.Annals of the Rheumatic Diseases, 1973
- Synovitis of recent onset. A clinicopathologic study during the first month of diseaseArthritis & Rheumatism, 1972
- A histopathological and pharmacological analysis of the mode of action of non‐steroidal anti‐inflammatory drugsThe Journal of Pathology, 1971