Image-based Multilevel Subdivision of M1 Category in TNM Staging System for Metastatic Nasopharyngeal Carcinoma

Authors:
  • LSLujun Shen
    Lujun Shen
  • WLWang Li
    Wang Li
  • SWSiyang Wang
    Siyang Wang
  • GXGuofeng Xie
    Guofeng Xie
  • QZQi Zeng
    Qi Zeng
  • CCChen Chen
    Chen Chen
  • FSFeng Shi
    Feng Shi
  • YZYing Zhang
    Ying Zhang
  • MWMing Wu
    Ming Wu
  • WSWanhong Shu
    Wanhong Shu
  • CPChangchuan Pan
    Changchuan Pan
  • YXYunfei Xia
    Yunfei Xia
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Abstract
The multilevel nomenclature system for precise M1 category subdivision could serve as a bridge toward personalized treatment under the guidance of modern imaging techniques and is recommended for patients with metachronous metastasic nasopharyngeal carcinoma. PurposeTo establish an image-based M1 category subdivision system for personalized prognosis prediction and treatment planning in patients with metastatic nasopharyngeal carcinoma (NPC).Materials and MethodsA total of 1172 patients with metachronous metastasic NPC were retrospectively enrolled (the dataset is from Sun Yat-sen University Cancer Center for derivation, and the combined datasets are from Guangzhou Medical University Cancer Center and the Fifth Affiliated Hospital of Sun Yat-sen University for validation). The Ethics Committee of the three centers approved this study. A general subdivision system of the M1 category was established on the basis of the most influential metastatic features for overall survival (OS). The following multilevel subdivision system for precise subdivision of the M1 category was designed: M [number of locations]-Location [number of lesions], with B indicating bone, L indicating the lung, H indicating the liver, and N indicating a node. The correlation of the M1 subdivis...

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