Novel Antiparasitic Activity of the Antifungal Lead Occidiofungin
- 22 July 2020
- journal article
- research article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 64 (8)
Abstract
Novel antiparasitic activity was observed for the antifungal occidiofungin. It efficaciously and irreversibly inhibited the zoonotic enteric parasite Cryptosporidium parvum in vitro with limited cytotoxicity (50% effective concentration [EC 50 ] = 120 nM versus 50% cytotoxic concentration [TC 50 ] = 988 nM), and its application disrupted the parasite morphology. This study expands the spectrum of activity of a glycolipopeptide named occidiofungin.Keywords
Funding Information
- HHS | NIH | National Institute of Allergy and Infectious Diseases (R41 AI131792, R42 AI131792)
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