Effect of Gabapentin vs Pregabalin on Pain Intensity in Adults With Chronic Sciatica
Authors:
Open Access
- 1 January 2019
- journal article
- research article
- Published by American Medical Association (AMA) in JAMA Neurology
- Vol. 76 (1) , 28-34
Abstract
Chronic sciatica (CS), like most neuropathic pain states, is often resistant to simple treatment regimens.1,2 Chronic sciatica is sciatica lasting longer than 3 months.3 Neuropathic pain states are typically managed by super-adding anticonvulsant drugs onto simple drug regimens. The drugs most commonly used are gabapentin (GBP) or pregabalin (PGB). Chronic sciatica has therefore been increasingly treated with super-added GBP or PGB.1,2,4 Pregabalin and GBP are both analogs of γ-aminobutyric acid, a substance known to modulate calcium channel subunits. Both GBP and PGB may therefore possibly act by decreasing neurotransmitter release associated with central sensitization in CS and neuropathic pain.Keywords
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