Development of a Thymectomy Trial in Nonthymomatous Myasthenia Gravis Patients Receiving Immunosuppressive Therapy
Authors:
- GIL I. WolfeGWGIL I. Wolfe
- Alfred JaretzkiAJAlfred Jaretzki
- 1 September 2003
- journal article
- research article
- Published by Wiley in Annals of the New York Academy of Sciences
- Vol. 998 (1) , 473-480
Abstract
Abstract: Thymectomy has been regularly used in the management of nonthymomatous autoimmune myasthenia gravis (MG), but its benefits have not been established in a randomized, controlled trial. The widespread use of thymectomy in MG patients without thymoma is largely based on retrospective, nonrandomized case series that have produced a consensus that the procedure is sometimes beneficial. Still, the benefits and utilization of thymectomy are actively debated among MG experts. In this paper, we describe the development of a multicenter, international trial to determine whether extended transsternal thymectomy reduces corticosteroid requirements for patients with generalized AChR antibody‐positive nonthymomatous MG.Keywords
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