An Efficient Method for Enhancing the Reactivity and Flexibility of [18F]Fluoride Towards Nucleophilic Substitution Using Tetraethylammonium Bicarbonate

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Abstract
The standard method used to generate reactive [18F]fluoride for [18F]radiolabelling is to trap it on an anion‐exchange cartridge then elute it with a basic aqueous solution, which is then subjected to azeotropic evaporation to remove water. We have now developed a method through the use of tetraethylammonium hydrogen carbonate in which we can obtain efficient recovery of [18F]fluoride (up to 99 %), remove the requirement for the time‐consuming and inefficient azeotropic evaporation process and produce a reactive [18F]fluoride that can undergo a wide range of aliphatic and aromatic [18F]nucleophilic substitutions in up to 93 % radiochemical conversion at end‐of‐synthesis in the presence or without water.

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