Synthesis of Indolyl‐7‐azanorbornanes by Decomposition of Tetrahydro‐1,2,3‐triazepines
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Open Access
- 10 April 2025
- journal article
- research article
- Published by Wiley in Advanced Synthesis & Catalysis
- Vol. 367 (10) , e202500047
Abstract
We report a new method for the synthesis of indolyl‐7‐azanorbornanes. The process involves the generation of a meta‐stable tetrahydro‐1,2,3‐triazepine intermediate that decomposes by extrusion of molecular nitrogen and ultimately leads to the formation of the observed products. The intermediacy of the triazepine intermediate was substantiated by trapping with allyl bromide to give an allylated triazepine compound that was sufficiently stable to be fully characterized in the usual ways.Keywords
Funding Information
- National Institutes of Health (NIGMS R01GM147650)
- National Science Foundation (CHE-1856273)
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